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A effective DNA vaccine against diverse genotype J infectious hematopoietic necrosis virus strains prevalent in China.

Vaccine - 25 Apr 2017

Xu Liming, Zhao Jingzhuang, Liu Miao, Kurath Gael, Ren Guangming, Lapatra Scott E, Yin Jiasheng, Liu Hongbai, Feng Jian, Lu Tongyan

Abstract excerpt

Infectious hematopoietic necrosis virus (IHNV) is the most important pathogen threatening the aquaculture of salmonid fish in China. In this study, a DNA vaccine, designated pIHNch-G, was constructed with the glycoprotein (G) gene of a Chinese IHNV isolate SD-12 (also called Sn1203) of genotype J. The minimal dose of vaccine required, the expression of the Mx-1 gene in the muscle (vaccine delivery site) and...

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PMID: 28343776
DOI: 10.1016/j.vaccine.2017.03.047

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