Article
High HIV-1 genetic diversity and low prevalence of transmitted drug resistance among treatment-naive people living with HIV in Madagascar.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2024
Rakotomalala Fetra Angelot, Butel Christelle, Rasamoelina Tahinamandranto, Serrano Laetitia, Vidal Nicole, Randriarimanana Santatriniaina Hajanirina Dauphin, Maharavo Luca, Randriamananjara Hajanirina Nathanaella, Fernandez-Nuñez Nicolas, Rabetokotany Felana Ranaivo, Rakoto Danielle Aurore Doll, Delaporte Eric, Peeters Martine, Babin François-Xavier, Samison Luc Hervé, Nerrienet Eric, Ayouba Ahidjo
Abstract excerpt
BACKGROUND AND OBJECTIVES: Data on HIV drug resistance in Madagascar are rare and outdated. In this study, we assessed the prevalence of HIV drug resistance mutations to antiretrovirals (ARVs) and genetic diversity of circulating strains in treatment-naive people living with HIV (PLHIV) in Madagascar. MATERIALS AND METHODS: We amplified the protease (PR), fragments of the Reverse Transcriptase (RT) and Integrase...
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