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Fetal hypoxia exposure induces Hif1a activation and autophagy in adult ovarian granulosa cells

3 Oct 2024

Abstract excerpt

Environmental hypoxia adversely impacts the reproduction of humans and animals. Previously, we showed that fetal hypoxia exposure led to granulosa cell (GC) autophagic cell death via the Foxo1/Pi3k/Akt pathway. However, the upstream regulatory mechanisms underlying GC dysfunction remain largely unexplored. Here, we tested the hypothesis that fetal hypoxia exposure altered gene expression programs in adult GCs and...

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PMID: 39361887
DOI: 10.1093/biolre/ioae141

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