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Article

Regionally enriched rare deleterious exonic variants in the UK and Ireland.

Nature communications - 2 Oct 2024

Halachev Mihail, Gountouna Viktoria-Eleni, Meynert Alison, Tzoneva Gannie, Shuldiner Alan R, Semple Colin A, Wilson James F

Abstract excerpt

It is unclear how patterns of regional genetic differentiation in the UK and Ireland might impact the protein-coding fraction of the genome. We exploit UK Biobank (UKB) and Viking Genes whole exome sequencing data to study regional genetic differentiation across the UK and Ireland in protein coding genes, encompassing 44,696 unrelated individuals from 20 regions of origin. We demonstrate substantial exonic...

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Identifiers

PMID: 39358353
DOI: 10.1038/s41467-024-51604-2
PMCID: PMC11446911

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