Article
N4-Hydroxycytidine/molnupiravir inhibits RNA virus-induced encephalitis by producing less fit mutated viruses.
PLoS pathogens - 1 Sept 2024
Ojha Durbadal, Hill Collin S, Zhou Shuntai, Evans Alyssa, Leung Jacqueline M, Schneider Christine A, Amblard Franck, Woods Tyson A, Schinazi Raymond F, Baric Ralph S, Peterson Karin E, Swanstrom Ronald
Abstract excerpt
A diverse group of RNA viruses have the ability to gain access to the central nervous system (CNS) and cause severe neurological disease. Current treatment for people with this type of infection is generally limited to supportive care. To address the need for reliable antivirals, we utilized a strategy of lethal mutagenesis to limit virus replication. We evaluated ribavirin (RBV), favipiravir (FAV) and...
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