Identification of key hub genes in knee osteoarthritis through integrated bioinformatics analysis

Abstract excerpt

Knee osteoarthritis (KOA) is a common chronic joint disease globally. Synovial inflammation plays a pivotal role in its pathogenesis, preceding cartilage damage. Identifying biomarkers in osteoarthritic synovial tissues holds promise for early diagnosis and targeted interventions. Gene expression profiles were obtained from the Gene Expression Omnibus database. Subsequent analyses included differential expression...

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• Cytokine Signaling Pathways and Interactions
• interferon and immune responses
• Osteoarthritis Treatment and Mechanisms