Fusobacterium Nucleatum Promotes Microsatellite Instability in Colorectal Carcinoma Through Up‐regulation of miRNA‐155‐5p‐Targeted Inhibition of MSH6 via the TLR4/NF‐κB Signaling Pathway.

Abstract excerpt

Fusobacterium nucleatum (Fn) is significantly associated with poor prognosis in colorectal carcinoma (CRC), however, mechanisms of Fn in DNA mismatch repair (MMR) and microsatellite instability (MSI) in CRC have not been fully elucidated. Clinical samples are collected to analyze the relationship between Fn abundance and microsatellite stability. Tumor cells are treated with Fn to detect the expression of...

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