Article
Mechanisms of transcriptional regulation in Anopheles gambiae revealed by allele-specific expression.
Proceedings. Biological sciences - 1 Sept 2024
Dyer Naomi A, Lucas Eric R, Nagi Sanjay C, McDermott Daniel P, Brenas Jon H, Miles Alistair, Clarkson Chris S, Mawejje Henry D, Wilding Craig S, Halfon Marc S, Asma Hasiba, Heinz Eva, Donnelly Martin J
Abstract excerpt
Malaria control relies on insecticides targeting the mosquito vector, but this is increasingly compromised by insecticide resistance, which can be achieved by elevated expression of detoxifying enzymes that metabolize the insecticide. In diploid organisms, gene expression is regulated both in cis, by regulatory sequences on the same chromosome, and by trans acting factors, affecting both alleles equally....
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