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Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study.

Diabetes, obesity & metabolism - 1 Dec 2024

Yuan Hai-Yang, Liu Wen-Yue, Feng Gong, Chen Sui-Dan, Jin Xin-Zhe, Chen Li-Li, Song Zi-Jun, Li Ke, Byrne Christopher D, Targher Giovanni, Tian Na, Li Gang, Zhang Xin-Lei, George Jacob, Zhou Meng, Wang Fudi, Zheng Ming-Hua

Abstract excerpt

AIMS: To explore the associations between cuprotosis-related genes (CRGs) across different stages of liver disease in metabolic dysfunction-associated fatty liver disease (MAFLD), including hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We analysed several bulk RNA sequencing datasets from patients with MAFLD (n = 331) and MAFLD-related HCC (n = 271) and two MAFLD single-cell RNA sequencing datasets. To...

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PMID: 39285685
DOI: 10.1111/dom.15946

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