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STAT3 interactome predicts presence of proteins that regulate immune system in oral squamous cell carcinoma

3 Sept 2024

Abstract excerpt

OBJECTIVES: Signal transducer and activator of transcription 3 (STAT3) is one of the key proliferation mechanism-related proteins that helps in oral squamous cell carcinoma (OSCC) progression. Immune evasion by STAT3 is mediated by the JAK2/STAT3/PDL1 signaling axis. Based on previous findings, we hypothesized that STAT3-binding partners participate in the inhibition of anti-tumor activity in OSCC. METHODS: A 3D...

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PMID: 39237001
DOI: 10.1016/j.job.2024.09.002

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