Article
Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.
Nature communications - 4 Sept 2024
Ambalavanan Amirthagowri, Chang Le, Choi Jihoon, Zhang Yang, Stickley Sara A, Fang Zhi Y, Miliku Kozeta, Robertson Bianca, Yonemitsu Chloe, Turvey Stuart E, Mandhane Piushkumar J, Simons Elinor, Moraes Theo J, Anand Sonia S, Paré Guillaume, Williams Janet E, Murdoch Brenda M, Otoo Gloria E, Mbugua Samwel, Kamau-Mbuthia Elizabeth W, Kamundia Egidioh W, Gindola Debela K, Rodriguez Juan M, Pareja Rossina G, Sellen Daniel W, Moore Sophie E, Prentice Andrew M, Foster James A, Kvist Linda J, Neibergs Holly L, McGuire Mark A, McGuire Michelle K, Meehan Courtney L, Sears Malcolm R, Subbarao Padmaja, Azad Meghan B, Bode Lars, Duan Qingling
Abstract excerpt
Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort...
Topics
- Humans
- Milk, Human
- Female
- Genome-Wide Association Study
- Oligosaccharides
- Sialyltransferases