Article
Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism.
Nature communications - 30 Aug 2024
Solé-Navais Pol, Juodakis Julius, Ytterberg Karin, Wu Xiaoping, Bradfield Jonathan P, Vaudel Marc, LaBella Abigail L, Helgeland Øyvind, Flatley Christopher, Geller Frank, Finel Moshe, Zhao Mengqi, Lazarus Philip, Hakonarson Hakon, Magnus Per, Andreassen Ole A, Njølstad Pål R, Grant Struan F A, Feenstra Bjarke, Muglia Louis J, Johansson Stefan, Zhang Ge, Jacobsson Bo
Abstract excerpt
Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring...
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