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Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans

23 Aug 2024

Abstract excerpt

Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to programmed cell death in the C. elegans soma, the selection of germ cells undergoing apoptosis is stochastic. By live-tracking individual germ cells at the pachytene stage, we found that germ cells smaller than their...

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PMID: 39178318
DOI: 10.1371/journal.pbio.3002775

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