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Evolutionary Analysis of the Mammalian IL‐17 Cytokine Family Suggests Conserved Roles in Female Fertility

1 Aug 2024

Abstract excerpt

PROBLEM: The interleukin-17 (IL-17) family includes pro-inflammatory cytokines IL-17A-F with important roles in mucosal defence, barrier integrity and tissue regeneration. IL-17A can be dysregulated in fertility complications, including pre-eclampsia, endometriosis and miscarriage. Because mammalian subclasses (eutherian, metatherian, and prototherian) have different related reproductive strategies, IL-17 genes...

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PMID: 39177066
DOI: 10.1111/aji.13907

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