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Combined strategies with PARP inhibitors for the treatment of BRCA wide type cancer

2 Aug 2024

Abstract excerpt

Genomic instability stands out as a pivotal hallmark of cancer, and PARP inhibitors (PARPi) emerging as a groundbreaking class of targeted therapy drugs meticulously crafted to inhibit the repair of DNA single-strand breaks(SSB) in tumor cells. Currently, PARPi have been approved for the treatment of ovarian cancer, pancreatic cancer, breast cancer, and prostate cancer characterized by homologous...

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PMID: 39156700
DOI: 10.3389/fonc.2024.1441222

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