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Impact of molecular testing on the surgical management of advanced epithelial ovarian cancer.

Critical reviews in oncology/hematology - 1 Oct 2024

Colombo Pierre-Emmanuel, Taoum Christophe, Fabbro Michel, Quesada Stanislas, Rouanet Philippe, Ray-Coquard Isabelle

Abstract excerpt

Ovarian carcinoma remains the most lethal gynaecologic malignancy. Half of all high-grade serous ovarian cancers (HGSOCs) have a homologous recombination deficiency (HRD) with regard to the repair of double-strand DNA breaks and are candidate to receive maintenance treatment with PARP inhibitors. While a wealth of literature exists regarding the therapeutic guidance of patients from a medical standpoint, the...

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PMID: 39111459
DOI: 10.1016/j.critrevonc.2024.104469

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