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Article

Comprehensive analysis of single-nucleotide variants and alternative polyadenylation between inbred and outbred pigs.

International journal of biological macromolecules - 1 Oct 2024

Han Yu, Tu Weilong, Zhang Yingying, Huang Ji, Meng Xiangge, Wu Qingqing, Li Songyu, Liu Bang, Michal Jennifer J, Jiang Zhihua, Tan Yongsong, Zhou Xiang, Wang Hongyang

Abstract excerpt

Inbreeding can lead to the accumulation of homozygous single nucleotide polymorphisms (SNPs) in the genome, which can significantly affect gene expression and phenotype. In this study, we examined the impact of homozygous SNPs resulting from inbreeding on alternative polyadenylation (APA) site selection and the underlying genetic mechanisms using inbred Luchuan pigs. Genome resequencing revealed that inbreeding...

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PMID: 39098700
DOI: 10.1016/j.ijbiomac.2024.134416

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