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Article

A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification.

Archives of toxicology - 1 Oct 2024

Hu Jing, Wang Shizhi, Zhang Xing, Yan Wenjing, Liu Haohan, Chen Xue, Nie Yamei, Liu Fengying, Zheng Yun, Lu Yiran, Jin Hua

Abstract excerpt

Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m6A) modifications. A better understanding of the association of these genetic variants with susceptibility to cervical cancer (CC) can promote advances in disease screening and treatment. Genome-wide identification of m6A-associated functional SNPs for CC was performed using the TCGA and JENGER databases, incorporating the...

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PMID: 38992170
DOI: 10.1007/s00204-024-03820-4

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