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Cytoplasmic Lipid Droplets Predict Worse Prognosis in Diffuse Large B-Cell Lymphoma: Next-Generation Sequencing Deciphering Lipogenic Genes.

The American journal of surgical pathology - 1 Nov 2024

Wang Shu-Hsien, Chiang Po-Min, Su Yung-Yeh, Yu Yu-Ting, Chen Ya-Ping, Chen Tsai-Yun, Medeiros L Jeffrey, Chu Chang-Yao, Chen Peng-Chieh, Chang Kung-Chao

Abstract excerpt

Burkitt lymphoma is characterized by high cell turnover and numerous cytoplasmic vacuoles that are demonstrated to be lipid droplets (LDs) decorated by adipophilin. By contrast, cytoplasmic vacuoles are variably observed in diffuse large B-cell lymphoma (DLBCL) and less well characterized. In this study, we first validated in DLBCL that cytoplasmic vacuoles are indeed LDs by Oil-red-O stain, Bodipy fluorescent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38979928
DOI: 10.1097/PAS.0000000000002280

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