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Article

Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect.

Journal for immunotherapy of cancer - 21 Jun 2024

Lu Conghua, Gao Ziyuan, Wu Di, Zheng Jie, Hu Chen, Huang Daijuan, He Chao, Liu Yihui, Lin Caiyu, Peng Tao, Dou Yuanyao, Zhang Yimin, Sun Fenfen, Jiang Weiling, Yin Guoqing, Han Rui, He Yong

Abstract excerpt

BACKGROUND: The dynamic interplay between tyrosine kinase inhibitors (TKIs) and the tumor immune microenvironment (TME) plays a crucial role in the therapeutic trajectory of non-small cell lung cancer (NSCLC). Understanding the functional dynamics and resistance mechanisms of TKIs is essential for advancing the treatment of NSCLC. METHODS: This study assessed the effects of short-term and long-term TKI treatments...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38908857
DOI: 10.1136/jitc-2024-009165
PMCID: PMC11328648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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