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Article

Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons.

Stem cell reports - 9 Jul 2024

Scaber Jakub, Thomas-Wright Iona, Clark Alex J, Xu Yinyan, Vahsen Björn F, Carcolé Mireia, Dafinca Ruxandra, Farrimond Lucy, Isaacs Adrian M, Bennett David L, Talbot Kevin

Abstract excerpt

Induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) from patients with amyotrophic lateral sclerosis (ALS) and the C9ORF72 hexanucleotide repeat expansion (HRE) have multiple cellular phenotypes, but which of these accurately reflect the biology underlying the cell-specific vulnerability of ALS is uncertain. We therefore compared phenotypes due to the C9ORF72 HRE in MNs with sensory neurons (SNs),...

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Identifiers

PMID: 38876108
DOI: 10.1016/j.stemcr.2024.05.008
PMCID: PMC11252479

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