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Article

Distinguishing recrudescence from reinfection in lymphatic filariasis.

EBioMedicine - 1 Jul 2024

Choi Young-Jun, Fischer Kerstin, Méité Aboulaye, Koudou Benjamin G, Fischer Peter U, Mitreva Makedonka

Abstract excerpt

BACKGROUND: The Global Program to Eliminate Lymphatic Filariasis (GPELF) is the largest public health program based on mass drug administration (MDA). Despite decades of MDA, ongoing transmission in some countries remains a challenge. To optimise interventions, it is critical to differentiate between recrudescence and new infections. Since adult filariae are inaccessible in humans, deriving a method that relies...

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PMID: 38848649
DOI: 10.1016/j.ebiom.2024.105188
PMCID: PMC11200287

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