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Article

Optimization of genetic distance threshold for inferring the CRF01_AE molecular network based on next-generation sequencing.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Hu Lijuan, Zhao Bin, Liu Mingchen, Gao Yang, Ding Haibo, Hu Qinghai, An Minghui, Shang Hong, Han Xiaoxu

Abstract excerpt

Introduction: HIV molecular network based on genetic distance (GD) has been extensively utilized. However, the GD threshold for the non-B subtype differs from that of subtype B. This study aimed to optimize the GD threshold for inferring the CRF01_AE molecular network. Methods: Next-generation sequencing data of partial CRF01_AE pol sequences were obtained for 59 samples from 12 transmission pairs enrolled from a...

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Identifiers

PMID: 38846352
DOI: 10.3389/fcimb.2024.1388059
PMCID: PMC11155296

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