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In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype.

Stem cell reviews and reports - 1 Aug 2024

Cao Ye, Boss Anna L, Bolam Scott M, Munro Jacob T, Crawford Haemish, Dalbeth Nicola, Poulsen Raewyn C, Matthews Brya G

Abstract excerpt

Cell surface marker expression is one of the criteria for defining human mesenchymal stem or stromal cells (MSC) in vitro. However, it is unclear if expression of markers including CD73 and CD90 reflects the in vivo origin of cultured cells. We evaluated expression of 15 putative MSC markers in primary cultured cells from periosteum and cartilage to determine whether expression of these markers reflects either...

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PMID: 38837115
DOI: 10.1007/s12015-024-10743-1
PMCID: PMC11319515

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