Article
A gene with a thousand alleles: The hyper-variable effectors of plant-parasitic nematodes.
Cell genomics - 12 Jun 2024
Sonawala Unnati, Beasley Helen, Thorpe Peter, Varypatakis Kyriakos, Senatori Beatrice, Jones John T, Derevnina Lida, Eves-van den Akker Sebastian
Abstract excerpt
Pathogens are engaged in a fierce evolutionary arms race with their host. The genes at the forefront of the engagement between kingdoms are often part of diverse and highly mutable gene families. Even in this context, we discovered unprecedented variation in the hyper-variable (HYP) effectors of plant-parasitic nematodes. HYP effectors are single-gene loci that potentially harbor thousands of alleles. Alleles...
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