Human plasma-like medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies

Abstract excerpt

ABSTRACT The fungal pathogen Cryptococcus neoformans (C. neoformans ) forms yeast cells of different sizes and morphological characteristics during infection. These features are usually not seen in standard laboratory in vitro conditions. Here, we describe in vivo cell morphologies when C. neoformans is grown in human plasma-like medium at 37°C, 5% CO 2 . We observed mixed-size populations of cells less than 1 µm...

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