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Article

Identification of a novel mutation in chibby family member 2 in a non-obstructive azoospermic patient.

Reproductive biology - 1 Jun 2024

Zhang Guohui, Ye Fei, Yang Yihong, Xiong Dongsheng, Zhi Weiwei, Wu Yang, Sun Yongkang, Zeng Jiuzhi, Liu Weixin

Abstract excerpt

Azoospermia constitutes a significant factor in male infertility, defined by the absence of spermatozoa in the ejaculate, afflicting 15% of infertile men. However, a subset of azoospermic cases remains unattributed to known genetic variants. Prior investigations have identified the chibby family member 2 (CBY2) as prominently and specifically expressed in the testes of both humans and mice, implicating its...

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PMID: 38733656
DOI: 10.1016/j.repbio.2024.100891

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