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Generation of human induced pluripotent stem cell lines derived from four Rett syndrome patients with MECP2 mutations.

Stem cell research - 1 Jun 2024

Mori Miyu, Yoshii Shoko, Noguchi Michiya, Takagi Daigo, Shimizu Tomoya, Ito Hidenori, Matsuo-Takasaki Mami, Nakamura Yukio, Takahashi Satoru, Hamada Hiromichi, Ohnuma Kiyoshi, Shiohama Tadashi, Hayashi Yohei

Abstract excerpt

Rett syndrome is characterized by severe global developmental impairments with autistic features and loss of purposeful hand skills. Here we show that human induced pluripotent stem cell (hiPSC) lines derived from four Japanese female patients with Rett syndrome are generated from peripheral blood mononuclear cells using Sendai virus vectors. The generated hiPSC lines showed self-renewal and pluripotency and...

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Identifiers

PMID: 38703668
DOI: 10.1016/j.scr.2024.103432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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