Estimating genomic relationships of metafounders across and within breeds using maximum likelihood, pseudo-expectation-maximization maximum likelihood and increase of relationships.

Abstract excerpt

BACKGROUND: The theory of "metafounders" proposes a unified framework for relationships across base populations within breeds (e.g. unknown parent groups), and base populations across breeds (crosses) together with a sensible compatibility with genomic relationships. Considering metafounders might be advantageous in pedigree best linear unbiased prediction (BLUP) or single-step genomic BLUP. Existing methods to...

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