Article
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Nature communications - 16 Apr 2024
Liu Chang, Das Raksha, Dijokaite-Guraliuc Aiste, Zhou Daming, Mentzer Alexander J, Supasa Piyada, Selvaraj Muneeswaran, Duyvesteyn Helen M E, Ritter Thomas G, Temperton Nigel, Klenerman Paul, Dunachie Susanna J, Paterson Neil G, Williams Mark A, Hall David R, Fry Elizabeth E, Mongkolsapaya Juthathip, Ren Jingshan, Stuart David I, Screaton Gavin R
Abstract excerpt
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-through infections with Omicron sub lineages BA.4 or BA.5. Twenty eight potent antibodies are isolated and characterised functionally, and in some cases structurally. Since the...
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