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Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease

23 Mar 2024

Abstract excerpt

IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. In this study, by using IgG4-RD patient peripheral blood mononuclear cells (PBMCs), IgG4-RD cell lines and Usp25 knockout mice, we show that ubiquitin-specific protease 25 (USP25) engages in multiple pathways to...

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PMID: 38521787
DOI: 10.1038/s41467-024-45977-7

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