Association between gut microbiota and Hirschsprung disease: a bidirectional two-sample Mendelian randomization study

Abstract excerpt

Background Several studies have pointed to the critical role of gut microbiota (GM) and their metabolites in Hirschsprung disease (HSCR) pathogenesis. However, the detailed causal relationship between GM and HSCR remains unknown. Methods In this study, we used two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between GM and HSCR, based on the MiBioGen Consortium’s genome-wide...

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• Congenital gastrointestinal and neural anomalies
• Fetal and Pediatric Neurological Disorders
• Gastrointestinal motility and disorders