Article
Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host.
Cell host & microbe - 10 Apr 2024
Pereira Gabriel Vasconcelos, Boudaud Marie, Wolter Mathis, Alexander Celeste, De Sciscio Alessandro, Grant Erica T, Trindade Bruno Caetano, Pudlo Nicholas A, Singh Shaleni, Campbell Austin, Shan Mengrou, Zhang Li, Yang Qinnan, Willieme Stéphanie, Kim Kwi, Denike-Duval Trisha, Fuentes Jaime, Bleich André, Schmidt Thomas M, Kennedy Lucy, Lyssiotis Costas A, Chen Grace Y, Eaton Kathryn A, Desai Mahesh S, Martens Eric C
Abstract excerpt
Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota...
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