Article
Individualized atomoxetine response and tolerability in children with ADHD receiving different dosage regimens: the need for CYP2D6 genotyping and therapeutic drug monitoring to dance together.
Translational psychiatry - 19 Mar 2024
Guo Hong-Li, Wu Dan-Dan, Fu Di, Li Yue, Wang Jie, Zhang Yuan-Yuan, Wang Wei-Jun, Huang Jian, Fang Wei-Rong, Xu Jing, Hu Ya-Hui, Liu Qian-Qi, Chen Feng
Abstract excerpt
Integrating CYP2D6 genotyping and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retrospective study was (1) to investigate the link between the efficacy and tolerability of atomoxetine in children with ADHD and plasma atomoxetine concentrations based on their CYP2D6 genotypes; (2) to...
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