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Early-life exposure to PM2.5 leads to ASD-like phenotype in male offspring rats through activation of PI3K-AKT signaling pathway.

Ecotoxicology and environmental safety - 1 Apr 2024

Li Kang, Liang Xiaotian, Liu Xiaohua, Geng Yanpei, Yan Jun, Tian Lei, Liu Huanliang, Lai Wenqin, Shi Yue, Xi Zhuge, Lin Bencheng

Abstract excerpt

Previous studies have shown that early-life exposure to fine particulate matter (PM2.5) is associated with an increasing risk of autism spectrum disorder (ASD), however, the specific sensitive period of ASD is unknown. Here, a model of dynamic whole-body concentrated PM2.5 exposure in pre- and early-postnatal male offspring rats (MORs) was established. And we found that early postnatal PM2.5 exposed rats showed...

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PMID: 38503106
DOI: 10.1016/j.ecoenv.2024.116222

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