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Article

Prognostic mutation signature would serve as a potential prognostic predictor in patients with diffuse large B-cell lymphoma.

Scientific reports - 14 Mar 2024

Cho Shih-Feng, Yeh Tsung-Jang, Wang Hui-Ching, Du Jeng-Shiun, Gau Yuh-Ching, Lin Yu-Yin, Chuang Tzer-Ming, Liu Yi-Chang, Hsiao Hui-Hua, Moi Sin-Hua

Abstract excerpt

The present study aimed to elucidate the prognostic mutation signature (PMS) associated with long-term survival in a diffuse large B-cell lymphoma (DLBCL) cohort. All data including derivation and validation cohorts were retrospectively retrieved from The Cancer Genome Atlas (TCGA) database and whole-exome sequencing (WES) data. The Lasso Cox regression analysis was used to construct the PMS based on WES data,...

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PMID: 38485750
DOI: 10.1038/s41598-024-56583-4
PMCID: PMC10940711

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