Efficacy of Poly(ADP-ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene-Mutated Metastatic Castration-Resistant Prostate Cancer: A US Food and Drug Administration Pooled Analysis.

doi:10.1200/JCO.23.02105

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Efficacy of Poly(ADP-ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene-Mutated Metastatic Castration-Resistant Prostate Cancer: A US Food and Drug Administration Pooled Analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2024

Fallah Jaleh, Xu Jianjin, Weinstock Chana, Gao Xin, Heiss Brian L, Maguire William F, Chang Elaine, Agrawal Sundeep, Tang Shenghui, Amiri-Kordestani Laleh, Pazdur Richard, Kluetz Paul G, Suzman Daniel L

Abstract excerpt

PURPOSE: We performed a pooled analysis of multiple trials of poly(ADP-ribose) polymerase inhibitors (PARPi) in metastatic castration-resistant prostate cancer (mCRPC) to investigate the efficacy of PARPi in each individual homologous recombination repair (HRR) mutated (m) gene. PATIENTS AND METHODS: We pooled patient-level data from trials of PARPi in mCRPC that reported mutation status in individual HRR genes....

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PMID: 38484203
DOI: 10.1200/JCO.23.02105
PMCID: PMC11095872

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