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Article

Precise fine-turning of GhTFL1 by base editing tools defines ideal cotton plant architecture.

Genome biology - 26 Feb 2024

Wang Guanying, Wang Fuqiu, Xu Zhongping, Wang Ying, Zhang Can, Zhou Yi, Hui Fengjiao, Yang Xiyan, Nie Xinhui, Zhang Xianlong, Jin Shuangxia

Abstract excerpt

BACKGROUND: CRISPR/Cas-derived base editor enables precise editing of target sites and has been widely used for basic research and crop genetic improvement. However, the editing efficiency of base editors at different targets varies greatly. RESULTS: Here, we develop a set of highly efficient base editors in cotton plants. GhABE8e, which is fused to conventional nCas9, exhibits 99.9% editing efficiency, compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38409014
DOI: 10.1186/s13059-024-03189-8
PMCID: PMC10895741

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