Article
Understanding Social, Cultural, and Religious Factors Influencing Medical Decision-Making on BRCA1/2 Genetic Testing in the Orthodox Jewish Community.
Public health genomics - 1 Jan 2024
Yi Haeseung, Trivedi Meghna S, Crew Katherine D, Schechter Isaac, Appelbaum Paul, Chung Wendy K, Allegrante John P, Kukafka Rita
Abstract excerpt
INTRODUCTION: Although the prevalence of a pathogenic variant in the BRCA1 and BRCA2 genes is about 1:400 (0.25%) in the general population, the prevalence is as high as 1:40 (2.5%) among the Ashkenazi Jewish population. Despite cost-effective preventive measures for mutation carriers, Orthodox Jews constitute a cultural and religious group that requires different approaches to BRCA1 and BRCA2 genetic testing...
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