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Vitamin D and Aging: Central Role of Immunocompetence

30 Jan 2024

Abstract excerpt

The pro-hormone vitamin D3 is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates via the transcription factor VDR (vitamin D receptor) the epigenome and transcriptome of human immune cells and controls in this way the expression of hundreds of vitamin D target genes. Since the myeloid linage of hematopoiesis is...

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PMID: 38337682
DOI: 10.3390/nu16030398

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