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Assessing the risk to develop a growing teratoma syndrome based on molecular and epigenetic subtyping as well as novel secreted biomarkers

29 Jan 2024

Abstract excerpt

In germ cell tumors (GCT), a growing teratoma during chemotherapy with decreasing tumor markers was defined as ‘growing teratoma syndrome` (GTS) by Logothetis et al., in 1982. So far, its pathogenesis and specific treatment options remain elusive. We aimed at updating the GTS definition based on molecular and epigenetic features as well as identifying circulating biomarkers. We selected 50 GTS patients for...

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PMID: 38296184
DOI: 10.1016/j.canlet.2024.216673

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