Article
A high-performance computational workflow to accelerate GATK SNP detection across a 25-genome dataset.
BMC biology - 25 Jan 2024
Zhou Yong, Kathiresan Nagarajan, Yu Zhichao, Rivera Luis F, Yang Yujian, Thimma Manjula, Manickam Keerthana, Chebotarov Dmytro, Mauleon Ramil, Chougule Kapeel, Wei Sharon, Gao Tingting, Green Carl D, Zuccolo Andrea, Xie Weibo, Ware Doreen, Zhang Jianwei, McNally Kenneth L, Wing Rod A
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) are the most widely used form of molecular genetic variation studies. As reference genomes and resequencing data sets expand exponentially, tools must be in place to call SNPs at a similar pace. The genome analysis toolkit (GATK) is one of the most widely used SNP calling software tools publicly available, but unfortunately, high-performance computing versions of...
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