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Article

Polygenic Risk in Families With Spontaneous Coronary Artery Dissection.

JAMA cardiology - 1 Mar 2024

Tarr Ingrid, Hesselson Stephanie, Troup Michael, Young Paul, Thompson Jamie-Lee, McGrath-Cadell Lucy, Fatkin Diane, Dunwoodie Sally L, Muller David W M, Iismaa Siiri E, Kovacic Jason C, Graham Robert M, Giannoulatou Eleni

Abstract excerpt

Importance: Spontaneous coronary artery dissection (SCAD) is a poorly understood cause of acute coronary syndrome that predominantly affects women. Evidence to date suggests a complex genetic architecture, while a family history is reported for a minority of cases. Objective: To determine the contribution of rare and common genetic variants to SCAD risk in familial cases, the latter via the comparison of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38265806
DOI: 10.1001/jamacardio.2023.5194
PMCID: PMC10809133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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