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Article

Genetic Variants of the Beta-Adrenergic Receptor Pathways as Both Risk and Protective Factors for Retinopathy of Prematurity.

American journal of ophthalmology - 1 Jul 2024

Paradis Hélène, Werdyani Salem, Zhai Guangju, Gendron Robert L, Tabrizchi Reza, McGovern Margaret, Jumper J Michael, Brinton Daniel, Good William V

Abstract excerpt

PURPOSE: There is strong evidence that genetic factors influence retinopathy of prematurity (ROP), a neovascular eye disease. It has been previously suggested that polymorphisms in the genes involved in β-adrenergic receptor (ADRβ) pathways could protect against ROP. Antagonists for the ADRβ are actively tested in clinical trials for ROP treatment, but not without controversy and safety concerns. This study was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38224928
DOI: 10.1016/j.ajo.2023.12.017

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