Article
A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants.
BMC biology - 22 Nov 2023
Rice Edward S, Alberdi Antton, Alfieri James, Athrey Giridhar, Balacco Jennifer R, Bardou Philippe, Blackmon Heath, Charles Mathieu, Cheng Hans H, Fedrigo Olivier, Fiddaman Steven R, Formenti Giulio, Frantz Laurent A F, Gilbert M Thomas P, Hearn Cari J, Jarvis Erich D, Klopp Christophe, Marcos Sofia, Mason Andrew S, Velez-Irizarry Deborah, Xu Luohao, Warren Wesley C
Abstract excerpt
BACKGROUND: The red junglefowl, the wild outgroup of domestic chickens, has historically served as a reference for genomic studies of domestic chickens. These studies have provided insight into the etiology of traits of commercial importance. However, the use of a single reference genome does not capture diversity present among modern breeds, many of which have accumulated molecular changes due to drift and...
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