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Article

First-Line Osimertinib for Previously Untreated Patients With NSCLC and Uncommon EGFR Mutations: The UNICORN Phase 2 Nonrandomized Clinical Trial.

JAMA oncology - 1 Jan 2024

Okuma Yusuke, Kubota Kaoru, Shimokawa Mototsugu, Hashimoto Kana, Kawashima Yosuke, Sakamoto Tomohiro, Wakui Hiroshi, Murakami Shuji, Okishio Kyoichi, Hayashihara Kenji, Ohe Yuichiro

Abstract excerpt

Importance: Non-small cell lung cancer (NSCLC) with uncommon EGFR mutations is a rare subgroup, composing 14% of all EGFR mutations. Objective: To determine the usefulness of osimertinib in previously untreated patients with metastatic NSCLC harboring uncommon EGFR mutations, excluding exon 20 insertion mutations. Design, Setting, and Participants: This multicenter, open-label, single-group, phase 2 nonrandomized...

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Identifiers

PMID: 37991747
DOI: 10.1001/jamaoncol.2023.5013
PMCID: PMC10666043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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