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Article

Genetic landscape of pediatric acute liver failure of indeterminate origin

16 Nov 2023

Abstract excerpt

BACKGROUND AND AIMS: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, the main causes are viral infections (12%-16%) and inherited metabolic diseases (14%-28%). Yet, in up to 50% of cases the underlying etiology remains elusive, challenging clinical management, including liver transplantation. We systematically studied indeterminate PALF cases referred for genetic evaluation by...

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PMID: 37976411
DOI: 10.1097/hep.0000000000000684

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