Article
Amplification of Wild-Type RET Represents a Novel Molecular Subtype of Several Cancer Types With Clinical Response to Selpercatinib.
JCO precision oncology - 1 Sept 2023
Gandhi Malini M, Ricciuti Biagio, Harada Guilherme, Repetto Matteo, Gildenberg Melissa S, Singh Ankit, Li Yvonne Y, Gagné Andréanne, Wang Xinan, Aizer Ayal, Fitzgerald Kelly, Nishino Mizuki, Alessi Joao, Pecci Federica, Di Federico Alessandro, Fisch Adam, Drilon Alexander, Nardi Valentina, Sholl Lynette, Awad Mark M, Rotow Julia
Abstract excerpt
PURPOSE: RET rearrangements and RET activating point mutations represent targetable genomic alterations in advanced solid tumors. However, the frequency and clinicopathologic characteristics of wild-type RET amplification in cancer and its potential role as a targetable oncogenic driver are not well-characterized. METHODS: In two institutional cohorts of patients with solid cancers from the Dana-Farber Cancer...
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