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Article

Neoadjuvant BRAF-targeted therapy for ameloblastoma of the mandible: an organ preservation approach.

Journal of the National Cancer Institute - 5 Apr 2024

Grynberg Shirly, Vered Marilena, Shapira-Frommer Ronnie, Asher Nethanel, Ben-Betzalel Guy, Stoff Ronen, Steinberg Yael, Amariglio Ninette, Greenberg Gahl, Barshack Iris, Toren Amos, Yahalom Ran, Schachter Jacob, Rechavi Gideon, Hirschhorn Ariel, Abebe Campino Gadi

Abstract excerpt

BACKGROUND: Ameloblastoma is a rare odontogenic neoplasm frequently located in the mandible. Standard treatment involves radical bone resection and immediate reconstruction, causing functional, aesthetic, and psychological impairments. The BRAF V600E mutation is present in approximately 80% of mandible ameloblastomas, and BRAF inhibitors have demonstrated sustained responses in unresectable cases. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37966914
DOI: 10.1093/jnci/djad232

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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