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Effect of Metformin on Epidermal Neural Crest Stem Cells and Their Potential Application in Ameliorating Paclitaxel-induced Neurotoxicity Phenotype.

Stem cell reviews and reports - 1 Jan 2024

Khodabakhsh Pariya, Asgari Taei Afsaneh, Shafaroodi Hamed, Pournajaf Safura, Dargahi Leila

Abstract excerpt

AIMS: Epidermal Neural Crest Stem Cells (EPI-NCSCs) have emerged as prospective ideal candidates to meet the fundamental requirements of cell-based therapies in neurodegenerative disorders. The present study aimed to identify the potential of metformin in driving EPI-NCSCs to neuronal/glial differentiation and express neurotrophic factors as well as assess their therapeutic potential for mitigating the main...

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PMID: 37924435
DOI: 10.1007/s12015-023-10642-x

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